Phagosome Neutrality in Host Defense
نویسنده
چکیده
Activation of proteases in the phagosomes of neutrophils occurs by neutralization of the phagosomal pH by NADPH oxidase. In this issue, Savina et al. (2006) show that dendritic cell phagosomes also recruit NADPH oxidase but with different results. Here, the neutralization of phagosomal pH reduces protease activity, which preserves antigens for crosspresentation on class I MHC molecules.
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ورودعنوان ژورنال:
- Cell
دوره 126 شماره
صفحات -
تاریخ انتشار 2006